7:00 am

Symposium Registration and Continental Breakfast (Vanity Fair Foyer and Pall Mall, Second Level)

Welcome and Opening Remarks (Vanity Fair Ballroom, Second Level)

8:00 am

OHTN: Sean Rourke (Scientific and Executive Director, OHTN)

ISNV:    Lynn Pulliam (Co-Chair, ISNV Meetings Committee)  

             Igor Koralnik (President, International Society for NeuroVirology)

Joint session 1: How aging and comorbidities affect the brain (Vanity Fair Ballroom, Second Level)

For people with HIV, how do aging and comorbidities affect their brains? What are the neuro-mechanisms? Are there strategies to protect the brain?

Moderators: Ron Rosenes and Scott Letendre

8:15 am

Dennis Kolson (University of Pennsylvania, Philadelphia, PA, USA)

Brain heme oxygenase-1 deficiency, oxidative stress and HIV-associated neurocognitive disorders: Potential therapeutic targeting

8:45 am

Alan Winston (Imperial College of London, London, UK)

Title TBD

9:15 am

Priscilla Hsue (University of California, San Francisco, San Francisco, CA, USA)

HIV, inflammation, and cardiovascular disease

9:45 am

Morning Break (Vanity Fair Foyer)

Joint session 2: Head and HAND - Biomarkers, neuroimaging, and neuroinflammation (Vanity Fair Ballroom, Second Level)

An in-depth discussion of advances in neuro-diagnostics.

Moderators: Avindra Nath and Chris Power

10:00 am

Tricia Burdo (Temple University, Philadelphia, PA, USA)

Peripheral biomarkers of HIV-associated neurocognitive disorders

10:20 am

Bruce Brew (University of New South Wales, Sydney, NSW, Australia)

HAND CSF biomarkers: Pitfalls and promises

10:40 am

Lucette Cysique (University of New South Wales, Sydney, NSW, Australia)

How good is MRI at elucidating evolving HIV neuropathogenesis? Research and clinical implications

10:55 am

Discussion

Concurrent Sessions

Joint session 3A: HIV and cognitive impairment (Vanity Fair Ballroom, Second Level)

Moderators: Kelly Jordan-Sciutto and Brian Wigdahl

Joint session 3B: HAND clinical phenotypes - Stability and risk factors (Sovereign Ballroom, Lobby Level)

Moderator: Sean B. Rourke

11:15 am

Andrew Levine (University of California, Los Angeles, Los Angeles, CA, USA)

Peripheral blood monocyte transcriptome at baseline implicates Wnt-signaling pathway in later neurocognitive change

11:15 am

Scott Letendre (University of California, San Diego, San Diego, CA, USA)

Neurocognitive decline in the modern treatment era: Measurement, correlates, and future directions

11:30 am

Valerie Wojna (University of Puerto Rico, San Juan, Puerto Rico)

Insulin receptor secretion is not associated with abnormal glucose metabolism in HIV-seropositive women

11:30 am

Benedetta Milanini (University of California, San Francisco, San Francisco, CA, USA)

HAND versus AD: New challenge in geriatric neuroHIV

11:45 am

Seung-Wan Yoo (Johns Hopkins University, Baltimore, MD, USA)

Evidence that dysfunctional endolysosomal biogenesis is associated with cognitive impairment in HIV-infected individuals; Agonists of TRPML1 may restore lysosomal function through luminal acidification

11:45 am

Lucette Cysique (The University of New South Wales, Sydney, Australia)

Title TBD

12:00 pm

Charles Mactutus (University of South Carolina, Columbia, SC, USA)

Progressive deficits in sustained attention with advancing age in the HIV-1 transgenic (Tg) rat

12:00 pm

Eileen Martin (Rush University, Chicago, IL, USA)

Sex differences in HIV and neurocognition

12:15 pm

James Becker (University of Pittsburgh, Pittsburgh, PA, USA)

Title TBD

12:15 pm

Lunch Break & Networking (talks resume at 1:45 pm)

Concurrent Tracks

ISNV Track: Viral Pathogenesis
(Vanity Fair Ballroom, Second Level)

OHTN Track: Implications of neurovirology discoveries for clinical care (Sovereign Ballroom, Lobby Level)

ISNV Session 1: CNS reservoirs and HIV eradication

Moderators: Kamel Khalili and Howard Gendelman

OHTN Session 1: HAND diagnostic issues - Healthcare practitioner perspectives

Why is it important? What are the implications for care?

Moderator: Julian Falutz

1:45 pm

Kamel Khalili (Temple University, Philadelphia, PA, USA)

Update on gene editing and eradication of HIV

1:45 pm

Jose Munoz-Moreno (Fundacio LLuita contra la SIDA, Barcelona, Spain)

Psychology / Neuropsychologic

2:00 pm

Paradigm Builder Lectureship

Jonathan Karn (Case Western Reserve University, Cleveland, OH, USA)

Control of HIV latency and transcription in microglial cells

Introduction by Kamel Khalili

2:00 pm

Reuben Robbins (Columbia University, New York, NY, USA)

Neuropsychologic

2:30 pm

Eric Cohen (McGill University, Montreal, Quebec, Canada)

Are macrophages a reservoir of HIV-1?

2:15 pm

Adriana Carvalhal (St. Michael's Hospital, Toronto, Ontario, Canada)

Psychiatric

2:50 pm

Howard Gendelman (University of Nebraska Medical Center, Omaha, NE, USA)

Development of long-acting reservoir targeted anti-HIV slow release compounds for viral eradication

2:30 pm

Lesley Fellows (McGill University, Montreal, Quebec, Canada)

Neurological

2:45 pm

Discussion

3:15 pm

Afternoon Break (Vanity Fair Foyer, Second Level)

ISNV Session 2: Extracellular vesicles in HIV neuropathogenesis

Moderators: Shilpa Buch and Ilker Sariyer

OHTN Session 2: Strategies to manage neurocognitive impairments

An overview of biomedical, clinical, and other interventions to help people with HIV delay or manage neurological issues

Moderator: John Gill

3:30 pm

Fatah Kashanchi (George Mason University, Manassas, VA, USA)

Exosomes from donor and recipient cells: Role of exosomes in HIV latency in cART treated cells

3:30 pm

Ned Sacktor (Johns Hopkins University, Baltimore, MD, USA)

Clinical management of HIV associated neurocognitive disorders

4:00 pm

Michal Toborek (University of Miami, Miami, FL, USA)

Extracellular vesicles are amyloid carriers in HIV-infected brains

3:50 pm

David Moore (University of California, San Diego, San Diego, CA, USA)

Exercise interventions

4:45 pm

Tribute to Dr. Donald Gilden (Windsor Ballroom, Lower Level)

4:10 pm

David Vance (University of Alabama at Birmingham, Birmingham, AL, USA)

Brain fitness interventions

6:30 pm

Junior Scientists/Women in NeuroVirology Event (Windsor Ballroom, Lower Level)

4:30 pm

Jose Munoz-Moreno (Fundacio LLuita contra la SIDA, Barcelona, Spain)

Psychological / CBT interventions

OHTN Session 3: HIV and brain in 90 minutes - Key implications of new research for clinical practice

Highlights of key findings. The 10 things you need to know in practice. Talk to the researchers. A special session for clinicians who were not able to attend the full conference.

Moderator: John Gill

5:00 pm

Brief presentations

5:30 pm

Panel discussion

Panelists: Bruce Brew, Lucette Cysique, Jose Munoz-Moreno, Reuben Robbins, David Moore, David Vance, Ned Sacktor, Lesley Fellows, Scott Letendre, Adriana Carvalhal, Eileen Martin, James Becker, Julian Falutz, Victor Valcour, Chris Power

6:30 pm

OHTN Reception and Poster Session