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Session Chairs: Joan Berman and Jay Rappaport |
8:00 am |
Steven D. Douglas (Plenary)
The Children’s Hospital of Philadelphia, Philadelphia, PA, USA |
The neurokinin-1 receptor and substance P: Modulation of HIV/SIV immune reactivation and leukocyte trafficking |
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8:30 am |
Donald Gilden
University of Colorado Denver School of Medicine, Aurora, CO, USA |
The immune repertoire in varicella zoster virus (VZV) vasculopathy and its association with VZV-induced cerebrovascular remodeling
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8:45 am |
Georgette Kanmogne
University of Nebraska Medical Center, Omaha, NE, USA |
HIV-1 induces cytoskeletal alteration and reorganization during endothelial-monocyte interactions: Modulatory role of CCR5 |
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9:00 am |
Yuri Persidsky
Temple University School of Medicine, Philadelphia, PA, USA |
Inhibition of poly(ADP-ribose) polymerase (PARP)-1 protects blood brain barrier in HIV CNS infection |
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Introduction by David Volsky |
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Michael G. Katze
University of Washington, Seattle, WA, USA |
Systems biology as a new approach for comprehensive studies of viral pathogenesis – But where are Google and IBM? |
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Session Chairs: Walter Royal, III, and Ruth Brack-Werner |
10:05 am |
Stephanie James
Postdoctoral Fellow, University of Colorado School of Medicine, Aurora, CO, USA |
VZV infection of human brain vascular adventitial fibroblasts down-regulates STAT mRNA expression and inhibits translocation of pSTAT to the nucleus |
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10:20 am |
Laura Ellis
Graduate Student, Beth Israel Deaconess Medical Center, Boston, MA, USA |
Role of agnogene deletion and archetype-like regulatory region in a JCV strain isolated from the brain of a patient with JCV Encephalopathy (JCVE) |
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10:35 am |
Matthew Cusick
Postdoctoral Fellow, University of Utah, Salt Lake City, UT, USA |
Macrophage infiltration of the brain in Theiler’s virus infection contributes to the development of seizures |
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10:50 am |
Amrita Datta Chaudhuri
Graduate Student, University of Nebraska Medical Center, Omaha, NE, USA |
Up-regulation of neuronal microRNA-142 in HIVE/SIVE leads to a decrease in monoamine oxidase A expression and activity by inhibiting SIRT1 |
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11:05 am |
Sarah Berth
Graduate Student, University of Illinois Chicago, Chicago, IL, USA |
The HIV glycoprotein gp120 impairs fast axonal transport through an axon-autonomous mechanism |
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Session Chairs: Shilpa Buch and Carlos Pardo |
11:20 am |
Robert F. Siliciano (Plenary)
The Johns Hopkins University School of Medicine, Baltimore, MD, USA |
New insights into highly active antiretroviral therapy for HIV infection: How HAART really works |
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11:50 am |
Glenn Rall
Fox Chase Cancer Center, Philadelphia, PA, USA |
Distinct interferon responses in neurons may contribute to survival during viral infection |
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12:05 pm |
Monique Anderson
National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA |
Characterization and behavior of T regulatory cells in HTLV-1 associated myelopathy / tropical spastic paraparesis |
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12:20 pm |
Yamil Gerena
University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico |
Secretion of soluble insulin receptor from human neuronal cells exposed to the cerebrospinal fluid from HIV-seropositive women correlates with cognitive performance |
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Empire State Ballroom IV-V |
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Uris and Juilliard Rooms |
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Session Chairs: Diane Lawrence and Roger Sorensen |
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Panel discussions on topic areas related to substance abuse and HIV (Igor Grant, Brian Wigdahl, Avindra Nath, Joan Berman, Kurt Hauser, Shilpa Buch) |
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NIDA Staff |
Workshop Overview |
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2:15 pm
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Panel A
(led by Joan Berman) |
Regulation of glial function and inflammation |
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Jacqueline Coley
Albert Einstein College of Medicine, Bronx, NY, USA |
Dopamine mediated changes in blood-brain barrier and neuroinflammation in the context of CNS HIV infection and substance abuse |
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Myosotys Rodriguez-Martinez
Universidad del Valle School of Medicine, Cali, Columbia |
Methadone and buprenorphine modulation on HIV-1 infection, inflammation, and neurotoxicity |
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Santosh Kumar
University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA |
Central role of cytochrome P450 2A6 in tobacco-mediated oxidative stress in macrophages and astrocytes |
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2:35 pm |
Panel B
(led by Avindra Nath) |
Molecular signaling in the CNS |
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Paula Desplats
University of California, San Diego, San Diego, CA, USA |
Effects of methamphetamine on the epigenetic regulation of HIV-1 in the human brain |
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Joyce Velez
University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico |
Cocaine and marijuana alter lipidomics in HAND |
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Jonathan Pitcher
Drexel University College of Medicine, Philadelphia, PA, USA |
Elevated ferritin heavy chain and dysregulated CXCL12/CXCR4 signaling within cortical neurons of drug abusers and HIV+ individuals |
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Erick Tatro
University of California San Diego, San Diego, CA, USA |
MicroRNA-9 is increased in CNS neurons in the HIV-infected brain and in methamphetamine exposure |
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2:55 pm |
Panel C
(led by Igor Grant) |
Behavioral outcomes of HIV and substance use |
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Erica Weber
University of California, San Diego, San Diego, CA, USA |
Methamphetamine use exacerbates HIV-associated neurocognitive impairment in acute and early HIV infection |
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Brook Henry
University of California San Diego, San Diego, CA, USA |
A Tale of Mice and Men: Translational cross-species assessment of inhibitory deficits in HIV and comorbid methamphetamine dependence using a novel human open-field paradigm |
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Svetlana Semenova University of California, San Diego, San Diego, CA, USA |
Expression of HIV gp120 protein increases sensitivity to the rewarding properties of methamphetamine in mice |
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3:15 pm |
Wrap Up / Future Directions |
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Broadway Room |
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Session Chairs: Robert Fujinami and Walter Royal, III |
2:10 pm |
Emily Leibovitch
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA |
HHV-6A infection enhances EAE severity in the common marmoset |
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2:35 pm |
Elodie Brison
INRS-Institut Armand-Frappier, Laval, Quebec, Canada |
Glutamate excitotoxicity is involved in motor dysfunction and paralysis following infection by a human respiratory corona virus |
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2:50 pm |
Alejandra Borjabad
St. Lukes-Roosevelt Hospital Center, Columbia University, New York, NY, USA |
Common transcriptional signatures in HIV-1-Associated Neurocognitive Disorder, Alzheimer’s Disease, and Multiple Sclerosis: Comparison with a mouse model of HAND |
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3:05 pm |
Armine Darbinyan
Temple University School of Medicine, Philadelphia, PA, USA |
Polyomavirus JC infection of human oligodendrocyte progenitor cells dysregulates production of chemokines and alters differentiation of oligodendrocytes |
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Session Chairs: Lena Al-Harthi and Dennis Kolson |
3:45 pm |
Marcus Kaul (Plenary)
Sanford-Burnham Medical Research Institute, La Jolla, CA, USA |
To prevent or repair HIV-associated brain injury |
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4:15 pm |
Eliseo Eugenin
University of Medicine and Dentistry, New Jersey - New Jersey Medical School, Newark, NJ, USA |
Identification of intracellular toxic signals required for bystander killing through gap junctions from HIV-infected astrocytes to uninfected astrocytes |
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4:30 pm |
Jennifer Gordon
Temple University School of Medicine, Philadelphia, PA, USA |
The impact of HIV-1 Tat on Pur-alpha mediated regulation of dendritic RhoA signaling |
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4:45 pm |
Andrew Levine
National Neurological AIDS Bank, Los Angeles, CA, USA |
Longitudinal analysis of interactive effects of host genotype, stimulant use, and HIV status upon neurocognitive functioning |
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Empire State Ballroom IV-V and Foyer |
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