8:30 am - 9:00 am

Welcoming Remarks

Brian Wigdahl, Lynn Pulliam, Jeymohan Joseph, and Pasquale Ferrante

9:00 am - 10:30 am

Session I

Brain as a reservoir for HIV

Session chairs: Richard Johnson and Peter G.E. Kennedy

9:00 am

Melissa Churchill (plenary)

Viral reservoir in brain

9:30 am

Ruth Brack-Werner

Mechanisms for cellular control of HIV replication in HIV reservoirs of the brain

9:45 am

Joan Berman

Characterization of stages of monocyte maturation/differentiation that facilitate their transmigration across the blood brain barrier and infection by HIV: Implications for NeuroAIDS

10:00 am

Joseph Mankowski

SIV Gag escape from CD8+ T cell control in the CNS during anti-retroviral treatment

10:15 am

Alfredo Garzino-Demo

Human beta-defensins and chemokine receptors in the central nervous system: potential factors in HIV infection

10:30 am - 11:00 am

Coffee Break

11:00 am - 12:30 pm

Session II

Surrogate markers for neuroglial injury

Session chairs: Brian Wigdahl and Don Gilden

11:00 am

Richard Price (plenary)

CSF biomarkers in evaluating HIV CNS disease activity and therapy

11:30 am

Armine Darbinyan

Role of JCV induced disbalance of chemokines in neuron-glia interaction

11:45 am

Tricia Burdo

Soluble CD163 as a plasma marker of HIV disease activation: Implications of macrophage-mediated immune responses

12:00 pm

Ronald Ellis

Predictors of incident distal neuropathic pain in HIV-infected individuals in the era of combination antiretroviral therapy

12:15 pm

Lynn Pulliam

Activated type 1 IFN monocyte phenotype correlates with MRS changes in HIV infection

12:30 pm - 2:00 pm

Lunch Break / Networking

2:00 pm - 3:30 pm

Session III

Therapeutic advances in CNS infections

Session chairs: Dana Gabuzda and Johnny He

2:00 pm

David Clifford (plenary)

Therapeutic challenges in HAND

2:30 pm

Giovanni Schifitto (plenary)

HIV-associated fatigue: Mechanisms and potential therapeutic interventions

3:00 pm

Carlo-Federico Perno (plenary)

Different evolution of HIV in CNS versus immunological compartment: Is it still clinically relevant?

3:30 pm - 4:00 pm

Coffee Break

4:00 pm - 5:30 pm

Session IV

Viral latency and molecular pathogenesis

Session chairs: Anna Teresa Palamara and Ravi Mahalingam

4:00 pm

Israel Steiner (plenary)

Herpes simplex virus type 1 and rabies virus neurotropism and spread in the CNS

4:30 pm

Avindra Nath

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

4:45 pm

Mineki Saito

Enhanced expression of OX40 by HTLV-1 Tax and its roles in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

5:00 pm

Giovanna De Chiara

Herpes simplex virus type 1 (HSV-1) induces multiple cleavages of amyloid precursor protein (APP) and Abeta accumulation in human and rat neuronal cells

5:15 pm

Barbara Krynska

Bone marrow-derived mesenchymal stem cell infection and transformation by JC virus in in vitro and in vivo models

5:30 pm - 6:00 pm

Special Lecture

2010 Paradigm Builder Lectureship

Introduction: Kamel Khalili

Joseph Glorioso

Design strategies for HSV neuro-therapeutics

6:00 pm - 7:30 pm

Special Lectures

International NeuroAIDS Research

Session Chairs

Mahendra Kumar and Jeymohan Joseph

6:00 pm

Bruce Shiramizu

CD14/CD16 and its HIV associated DNA viral load as marker of NeuroAIDS

6:30 pm

Brian Wigdahl

Viral and host genomic analyses to track HIV-1 disease in subtype B and C clinical cohorts

7:00 pm

Ravi Vasanthapuram

CSF viral load as a marker of progression in HIV -1 C clade infection

7:45 pm - 9:00 pm

Special Activity

Women in NeuroVirology Reception

Hotel Dei Cavalieri, 1st Floor, Gonzaga Room