Inaugural Bill Narayan Lectureship
Janice Clements
Professor and Director
Molecular & Comparative Pathobiology
Johns Hopkins University School of Medicine

One look at Dr. Janice Clements and you are staring at a pillar of strength. She is a dynamic leader who is an epitome of success and diligence. Within a short span of time, through her dedication and hard work, Dr. Clements has risen to the ranks of being the Vice Dean for the faculty, the Director of the Department of Comparative Medicine while leading a highly active retrovirus laboratory at the Johns Hopkins University. She spearheads a distinguished, multidisciplinary, research program that focuses on the molecular pathogenesis of lentiviruses. The main interest of her group is aimed at exploring the molecular basis of HIV-associated pathologies using the SIV-infected macaque model system. Pioneering work from her group has provided many of the foundational concepts that are currently being utilized to explore the pathogenesis of HIV and its effects on the immune and nervous systems.

Her scientific achievements are stellar. Dr. Clements was the first scientist to clone and sequence lentivirus genomes, thereby unraveling their complex genetic and molecular organization. Subsequently, a series of papers published by her elucidated the molecular basis for antigenic variation in the classic model of slow virus (visna) infection. Her ground-breaking work on the initial cloning of lentivirus genomes formed the basis for characterization of the AIDS virus, HIV, as a member of the lentivirus family. This landmark breakthrough has been critical in our understanding of lentivirus pathogenesis and its relationship with other oncogenic retroviruses. Role of macrophages as key target cells of lentivirus infection and central to the disease process had long been recognized. Dr. Clements' work on the molecular mechanisms of lentiviruses has provided further important insights into the pathogenesis of HIV including high susceptibility of infection and disease in macrophages in the end organs such as brain & lungs, role of antigenic variation of lentiviruses in persistence and evasion of immune control and the inability to develop successful immunological approaches for prevention of lentivirus infections.

As an extension of her work on lentiviruses she initiated work on the relevant SIV/macaque model of NeuroAIDS. She successfully developed the first virus molecular clones that were both macrophage-tropic as well as neurovirulent, and proceeded to demonstrate in depth the molecular basis for SIV neuropathogenesis in vivo. Work from her laboratory for the first time identified CD4-independent entry of virus into the cells of the CNS.

The neurovirulent SIV clone developed and characterized by her was critical for the progress of the "novel accelerated, consistent model" of HIV/AIDS. This model has proved a valuable tool to decipher the early effects of innate immunity in the brain. Work from her group has shed light on a novel signaling pathway in macrophages for SIV latency. Another application of this model has been its translational approach to decipher the anti-inflammatory and neuroprotective role of the drug minocycline. These key findings formed the basis for testing the role of minocycline in Multi-Center Clinic trials for the treatment of AIDS-associated pathologies. Using this model system, Dr. Clements has also established a latency model to study reservoirs of HIV in vivo as well as identifying a novel mechanism for the establishment of SIV/HIV latency in macrophages in the brain triggered by innate immune responses in vivo.

Besides academic achievement, Dr. Clements has also proved her caliber as an outstanding administrator who champions the causes of women and is their active voice in the field. At Hopkins she re-structured the Women's Leadership Council to actively undertake the mission of developing and mentoring women junior faculty and has been instrumental in fostering leadership skills aimed at preparing senior women faculty for leadership positions. In 2005, she organized the Women Professors Celebration at Johns Hopkins School of Medicine commemorating the promotion and celebration of women Professors, an event that was attended by celebrities such as Cokie Roberts (ABC News) and the 2005 Nobel Laurete Dr. Linda Buck. Great things DO indeed come in small packages!