Journal of NeuroVirology
Volume 22, Issue 2, April 2016

In this issue:

Original paper
Microglia-derived HIV Nef+ exosome impairment of the blood–brain barrier is treatable by nanomedicine-based delivery of Nef peptides
A. D. Raymond, P. Diaz, S. Chevelon, M. Agudelo, A. Yndart-Arias, H. Ding, A. Kaushik, R. Dev Jayant, R. Nikkhah-Moshaie, U. Roy, S. Pilakka-Kanthikeel & M. P. Nair

Original paper
Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation
Fiona M. Inglis, Kim M. Lee, Kevin B. Chiu, Olivia M. Purcell, Peter J. Didier, Kasi Russell-Lodrigue, Scott C. Weaver, Chad J. Roy & Andrew G. MacLean

Original paper
Effects of HIV and childhood trauma on brain morphometry and neurocognitive function
Georgina Spies, Fatima Ahmed-Leitao, Christine Fennema-Notestine, Mariana Cherner & Soraya Seedat

Original paper
Post-traumatic stress is associated with verbal learning, memory, and psychomotor speed in HIV-infected and HIV-uninfected women
Leah H. Rubin, Maria Pyra, Judith A. Cook, Kathleen M. Weber, Mardge H. Cohen, Eileen Martin, Victor Valcour, Joel Milam, Kathryn Anastos, Mary A. Young, Christine Alden, Deborah R. Gustafson & Pauline M. Maki

Original paper
Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients
Qing Ma, Florin Vaida, Jenna Wong, Chelsea A. Sanders, Yu-ting Kao, David Croteau, David B. Clifford, Ann C. Collier, Benjamin B. Gelman, Christina M. Marra, Justin C. McArthur, Susan Morgello, David M. Simpson, Robert K. Heaton, Igor Grant & Scott L. Letendre

Original paper
Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells
Mahfuz B. Khan, Michelle J. Lang, Ming-Bo Huang, Andrea Raymond, Vincent C. Bond, Bruce Shiramizu & Michael D. Powell

Original paper
Cell-free mitochondrial DNA in CSF is associated with early viral rebound, inflammation, and severity of neurocognitive deficits in HIV infection
Josué Pérez-Santiago, Rachel D. Schrier, Michelli F. de Oliveira, Sara Gianella, Susanna R. Var, Tyler R. C. Day, Miguel Ramirez-Gaona, Jesse D. Suben, Ben Murrell, Marta Massanella, Mariana Cherner, Davey M. Smith, Ronald J. Ellis, Scott L. Letendre & Sanjay R. Mehta

Original paper
Age exacerbates HIV-associated white matter abnormalities
Talia R. Seider, Assawin Gongvatana, Adam J. Woods, Huaihou Chen, Eric C. Porges, Tiffany Cummings, Stephen Correia, Karen Tashima & Ronald A. Cohen

Original paper
Cerebrospinal fluid white cell count: discriminatory or otherwise for enteroviral meningitis in infants and young children?
Natalie Woon Hui Tan, Elis Yuexian Lee, Gloria Mei Chin Khoo, Nancy Wen Sim Tee, Subramania Krishnamoorthy & Chew Thye Choong

Original paper
Antiretroviral treatment initiation does not differentially alter neurocognitive functioning over time in youth with behaviorally acquired HIV
Sharon L. Nichols, James Bethel, Bill G. Kapogiannis, Tiandong Li, Steven P. Woods, E. Doyle Patton, Weijia Ren, Sarah E. Thornton, Hanna O. Major-Wilson, Ana M. Puga, John W. Sleasman, Bret J. Rudy, Craig M. Wilson & Patricia A. Garvie

Original paper
Longitudinal assessment of fractional anisotropy alterations caused by simian immunodeficiency virus infection: a preliminary diffusion tensor imaging study
Zhenchao Tang, Enqing Dong, Jiaojiao Liu, Zhenyu Liu, Wenjuan Wei, Bo Wang, Hongjun Li & Jie Tian

Original paper
Detection of virus in CSF from the cases with meningoencephalitis by next-generation sequencing
Hongzhi Guan, Ao Shen, Xia Lv, Xunzhe Yang, Haitao Ren, Yanhuan Zhao, Yinxin Zhang, Yanping Gong, Peixiang Ni, Honglong Wu, Yicheng Zhu & Liying Cui

Short Communication
Subtype associations with HIV-associated neurocognitive disorder in China
Tyler R. C. Day, Davey M. Smith, Robert K. Heaton, Donald Franklin, Myers W. Tilghman, Scott Letendre, Hua Jin, Zunyou Wu, Chuan Shi, Xin Yu & Josué Pérez-Santiago

Case Report
Multiple strokes associated with herpes simplex virus type-2 infection: case report
Prajwol Joshi

Letter to the Editor
HIV immunodynamics and multiple sclerosis
Cieron Roe